Faking cellular suicide could help control inflammation
And that could help treat everything from hay fever to arthritis
AS PARACELSUS first pointed out in the 16th century, it is the dose that makes the poison. Inflammation, in particular, is vital to fighting infection or healing wounds. If it lingers, however, it can cause more harm than good. Chronic inflammation often impedes the very healing that it is meant to promote. Many drugs have been invented to combat that problem, but none is as effective as doctors would like. Now, as they describe in a paper in ACS Macro Letters, a team led by Mitsuhiro Ebara at the National Institute for Materials Science in Japan have come up with a new approach. They have worked out how to persuade cells in inflamed tissues to believe that other cells nearby have just committed suicide. REST
Bio-inspired approach to RNA delivery
By delivering strands of genetic material known as messenger RNA (mRNA) into cells, researchers can induce the cells to produce any protein encoded by the mRNA. This technique holds great potential for administering vaccines or treating diseases such as cancer, but achieving efficient delivery of mRNA has proven challenging.
Now, a team of MIT chemical engineers, inspired by the way that cells translate their own mRNA into proteins, has designed a synthetic delivery system that is four times more effective than delivering mRNA on its own. REST