A number of diseases—including diabetes, Alzheimer’s, and Parkinson’s—are associated with polypeptides that misfold and aggregate into fibrils that further clump together to form plaques. Researchers have now characterized the structure of an intermediate that leads to fibrils in the folding pathway of a polypeptide implicated in type 2 diabetes.
Disrupting formation of the intermediate structure may provide a new target for preventing or treating the disease, which is a growing public health problem. Type 2 diabetes is defined as an inability to produce enough of or respond properly to insulin. Consequently, glucose builds up in the bloodstream. Over time, the condition causes increasingly serious health problems.